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產(chǎn)品名稱: CH5424802
產(chǎn)品型號(hào): HY-13011
產(chǎn)品展商: TBD
產(chǎn)品文檔: 無相關(guān)文檔
簡(jiǎn)單介紹
產(chǎn)品類別：Angiogenesis/Receptor Tyrosine Kinases，產(chǎn)品編號(hào)：HY-13011，產(chǎn)品名稱：CH5424802，產(chǎn)品中文名稱：CH5424802，產(chǎn)品規(guī)格：5mg
CH5424802
的詳細(xì)介紹
HY-13011 CH5424802（別名CH5424802）機(jī)制：ALK
價(jià)格和可用性CH5424802 CH5424802技術(shù)參數(shù)：
CH5424802 M.Wt：482.62
CH5424802分子式：C30H34N4O2
CH5424802純度：> 98％
CH5424802貯存：貯存在-20℃2年
CH5424802 CAS號(hào)：1256580-46-7
CH5424802溶解性：DMSO≥13mg/mL水分<1.2mg/mL乙醇1.2mg/mL
生物活性CH5424802：
CH5424802是一種強(qiáng)效，選擇性，可口服ALK抑制劑。它具有獨(dú)特的化學(xué)腳手架，優(yōu)惠的抗腫瘤活性，對(duì)癌癥的ALK基因的改變，如非小細(xì)胞肺癌（NSCLC）細(xì)胞表達(dá)EML4-ALK融合和間變性大細(xì)胞**瘤（ALCL）細(xì)胞表達(dá)NPM-ALK融合在體內(nèi)和體外。 CH5424802 ALK L1196M，對(duì)應(yīng)網(wǎng)守突變賦予共同抵抗激酶抑制劑，抑制和阻斷EML4-ALK L1196M驅(qū)動(dòng)的細(xì)胞生長(zhǎng)。
HY-13011 CH5424802 (Synonyms CH 5424802) Mechanisms:ALK
CH5424802 Technical Data: Price and Availability of CH5424802
CH5424802 M.Wt: 482.62
CH5424802 Formula: C30H34N4O2
CH5424802 Purity: >98%
CH5424802 Storage: at -20℃ 2 years
CH5424802 CAS No.: 1256580-46-7
CH5424802 Solubility: DMSO ≥13mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL
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Biological Activity of CH5424802:
CH5424802 is a potent, selective, and orally available ALK inhibitor. which with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK, such as nonsmall cell lung cancer (NSCLC) cells expressing EML4-ALK fusion and anaplastic large-cell lymphoma (ALCL) cells expressing NPM-ALK fusion in vitro and in vivo. CH5424802 inhibited ALK L1196M, which corresponds to the gatekeeper mutation conferring common resistance to kinase inhibitors, and blocked EML4-ALK L1196M-driven cell growth.